“Wireframes just aren’t up to the job of showing subtle interaction details—the things that make the difference between an application that is a delight to use and one that frustrates and annoys. And even if you’re using a more sophisticated prototyping tool, you’re still not doing yourself any favors, because these tools don’t allow your designs to adapt to the multitude of different screen sizes that are out there.”
(Martin Polley a.k.a. @martinpolley ~ capcloud)